| 產(chǎn)品編號(hào) | bs-11928R-PE-Cy3 |
| 英文名稱 | Rabbit Anti-PTBP2/PE-Cy3 Conjugated antibody |
| 中文名稱 | PE-Cy3標(biāo)記的核糖核酸結(jié)合蛋白2抗體 |
| 別 名 | brPTB; FLJ34897; MIBP; Neural polypyrimidine tract binding protein; Neurally enriched homolog of PTB; Polypyrimidine tract binding protein 2; PTB; PTB like; PTB like protein; PTBLP; PTBP 2; PTBP-2; Splicing regulator; PTBP2_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, Dog, Cow, Horse, Zebrafish, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PTBP2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: PTBP-2 is a member of the polypyrimidine tract binding family of proteins. Predominantly expressed in brain, but also found in heart and skeletal muscle, PTBP-2 localizes to the nucleus and contains four RRM (RNA recognition motif) domains. PTBP-2 functions as an RNA-binding protein associated in a complex that is involved in the regulation of exon splicing and the stabilization of mRNAs in the cytoplasm. Six isoforms exist for PTBP-2 due to alternative splicing events. Isoforms 1 and 2 (also known as nPTB1 and nPTB2/PTBPLP-L, respectively) are neuronal-specific. Isoforms 3 and 4 (also known as nPTB3/PTBPLP-L and nPTB4, respectively) are found in non-neuronal tissues, as are isoforms 5 and 6 (also known as nPTB5/nPTB7/PTBPLP-S and nPTB6/nPTB8/PTBPLP-S, respectively). The existence of various isoforms may function to modulate the RNA-binding properties of PTBP-2 Function: PTPBP2 is an RNA-binding protein which binds to intronic polypyrimidine tracts. It binds to the CUCUCU splicing repressor element of the downstream control sequence (DCS) and mediates negative regulation of exons splicing. It may also have a role in the regulation of translation. PTBP2 is thought to be involved in the switch to neuronal specific alternative splicing patterns during neuronal differentiation. Subunit: Monomer. Interacts with NOVA1; the interaction is direct. Interacts with NOVA2; the interaction is direct (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Part of a ternary complex containing KHSRP and HNRPH1. Subcellular Location: Nuclear Tissue Specificity: Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues. Similarity: Contains 4 RRM (RNA recognition motif) domains. Database links: Entrez Gene: 58155 Human Entrez Gene: 56195 Mouse Omim: 608449 Human SwissProt: Q9UKA9 Human SwissProt: Q91Z31 Mouse Unigene: 269895 Human Unigene: 596061 Human Unigene: 29966 Mouse Unigene: 64916 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
