| 產(chǎn)品編號 | bs-1275R-BF594 |
| 英文名稱 | Rabbit Anti-FoxP1/BF594 Conjugated antibody |
| 中文名稱 | BF594標(biāo)記的叉頭蛋白P1抗體 |
| 別 名 | FLJ23741; Fork head related protein like B; Forkhead box P1; Forkhead box protein P1; 12CC4; foxp1; FOXP1_MOUSE; FOX P1; FOXP 1; Glutamine rich factor 1; hFKH1B; HSPC215; MGC12942; MGC88572; MGC99551; QRF 1; QRF1. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, Chicken, Dog, Cow, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 79kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse FoxP1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Function: Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development. Subunit: Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Subcellular Location: Nucleus. Tissue Specificity: Highest expression in the lung, brain, and spleen. Lower expression in heart, skeletal muscle, kidney, small intestine (isoform 3 not present) and liver. Similarity: Contains 1 C2H2-type zinc finger. Contains 1 fork-head DNA-binding domain. Database links: Entrez Gene: 27086?/span>Human Entrez Gene: 108655?/span>Mouse Entrez Gene: 297480?/span>Rat Omim: 605515?/span>Human SwissProt: Q9H334?/span>Human SwissProt: P58462?/span>Mouse SwissProt: Q498D1?/span>Rat Unigene: 431498?/span>Human Unigene: 59368?/span>Human Unigene: 234965?/span>Mouse Unigene: 485266?/span>Mouse Unigene: 33321?/span>Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Hox程序的信息輸出并有調(diào)節(jié)運動神經(jīng)元功能。FoxP1在Hox敏感型運動柱中表達，使FoxP1失活能消除運動神經(jīng)元Hox網(wǎng)絡(luò)的信息輸出，并將脊髓運動系統(tǒng)回復(fù)到原始狀。 FoxP1的減少同樣改變運動神經(jīng)元連結(jié)性模式， 肢體運動神經(jīng)似乎會隨機選擇目標(biāo)肌肉和作用路徑。單個的FoxP1轉(zhuǎn)錄因子能以Hox輔助因子的形式整合各種神經(jīng)元種類的連結(jié)性。 Hox蛋白：哺乳動物的同源盒基因由61個氨基酸殘基組成的蛋白質(zhì)保守結(jié)構(gòu)域,稱同源異型域。Hox基因在動物體的體節(jié)結(jié)構(gòu)分化等空間信息調(diào)控中起著重要作用,按特異的空間模式賦予每一體節(jié)其自身的特點。Hox基因不但影響胚胎發(fā)育，在生殖過程中也起著重要的調(diào)節(jié)作用. |
