| 產(chǎn)品編號 | bs-8458R-Gold |
| 英文名稱 | Rabbit Anti-PTRF/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的RNA聚合酶1和轉(zhuǎn)錄釋放因子抗體 |
| 別 名 | Cavin; MGC118550; FKSG13; OTTMUSP00000002049; polymerase I and transcript release factor; RNA polymerase I and transcript release factor; RP23-279L23.6; TTF I interacting peptide 12; 2310075E07Rik; AW546441; PTRF_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PTRF/RNA polymerase I and transcript release factor |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: Pausing of elongation complexes is mediated by the transcription termination factor TTF-I bound to the 'Sal box' terminator downstream of the rDNA transcription unit. PTRF is a Pol I and transcript release factor for dissociation of paused ternary complexes. Function: Plays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex. Subunit: Interacts with RNA polymerase I and TTF1. Binds the 3' end of pre-rRNA. Interacts with transcription factor ZNF148 (By similarity). Interacts with LIPE in the adipocyte cytoplasm. Subcellular Location: Cell membrane; caveola (surface). Cell membrane. Microsome. Cytoplasm; cytosol. Mitochondrion. Nucleus. Also found in the plasma membrane, microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions. Post-translational modifications: Phosphorylated. Present in active and inactive forms. Changes in phosphorylation pattern may alter activity (By similarity). Five truncated forms are found in the caveolae. These are thought to be the result of proteolysis and may be phosphorylation-dependent. DISEASE: Defects in PTRF are the cause of congenital generalized lipodystrophy type 4 (CGL4) [MIM:613327]. It is a disorder characterized by the association of congenital generalized lipodystrophy with muscular dystrophy and cardiac anomalies. Congenital generalized lipodystrophy is characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. Similarity: Belongs to the PTRF/SDPR family. Database links: UniProtKB/Swiss-Prot: Q6NZI2.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
