| 產(chǎn)品編號(hào) | bs-8034R-BF350 |
| 英文名稱(chēng) | Rabbit Anti-COMMD1/BF350 Conjugated antibody |
| 中文名稱(chēng) | BF350標(biāo)記的銅代謝結(jié)構(gòu)域蛋白1抗體 |
| 別 名 | C2orf5; COMD1; COMD1_HUMAN; COMM domain-containing protein 1; COMMD1; copper metabolism domain containing 1; MGC27155; MURR1; Protein Murr1. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 表觀(guān)遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 21kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human COMMD1/MURR1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Tissue specificity: Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta. Function: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Subunit: Monomer and homodimer. Interacts (via COMM domain) with COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8 and COMMD10 (via COMM domain). Identified in a complex with an E3 ubiquitin ligase complex composed of TCEB1/elongin C, CUL2, SOCS1 and RBX1. Interacts directly with SOCS1 and CUL2. Interacts directly the N-terminal region of ATP7B. Interacts with CCS, CDKN2A, RELA and NFKBIB. Identified in a complex with NF-kappa-B. Interacts with CLU. Tissue Specificity: Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta. Post-translational modifications: Ubiquitinated; undergoes both 'Lys-63'- and 'Lys-48'-linked polyubiquitination. Ubiquitinated by XIAP, leading to its proteasomal degradation. Similarity: Contains 1 COMM domain. Database links: UniProtKB/Swiss-Prot: Q8N668.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. COMMD蛋白家族中最典型的成員.它是一個(gè)多效性因子,參與許多生理活動(dòng),包括銅代謝、鈉運(yùn)輸、對(duì)核因子κB(NF-κB)及低氧誘導(dǎo)因子1(HIF-1)的調(diào)節(jié)等，COMMD廣泛存在于多細(xì)胞生物中,最典型的特征是它們的羧基端存在一個(gè)高度保守而獨(dú)特的結(jié)構(gòu)—COMMD結(jié)構(gòu)域,為蛋白質(zhì)間的相互作用提供了關(guān)鍵界面. 目前研究COMMD蛋白家族有10個(gè)成員,即COMMD1～10.COMMD1是COMMD蛋白家族中最先被證實(shí)且研究最為深入的蛋白質(zhì),在不同物種中廣泛表達(dá),在人類(lèi)的不同組織表達(dá)存在差異. |
