| 產(chǎn)品編號 | bs-11721R-PE-Cy5.5 |
| 英文名稱 | Rabbit Anti-Capicua/PE-Cy5.5 Conjugated antibody |
| 中文名稱 | PE-Cy5.5標(biāo)記的Capicua蛋白抗體 |
| 別 名 | Capicua homolog (Drosophila); Cic; CIC; KIAA0306; Protein capicua homolog; CIC_HUMAN. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 164kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Capicua (1475-1560aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Capicua is the mammalian ortholog of the drosophilia Cic gene and is part of the HMG-box protein superfamily. Expressed primarily in the fetal brain, Capicua functions as a transciptional repressor and is involved in the development of the nervous system through interaction with the ATXN1 protein. When ATXN1 assembles into stable complexes, it directly binds Capicua, thereby mediating both the activity and expression of Capicua. When Capicua is active, it is able to interact with other developmental proteins to restrict the growth of granule cells and regulate normal neuronal development. Disruptions in the the association of Capicua with proteins such as ATXN1 are thought to cause medulloblastoma, the most common form of perdiatric brain tumor arising from irregular growth of granule cells. Function: Transcriptional repressor which may play a role in development of the central nervous system (CNS). Subunit: Interacts with ATXN1 and ATXN1L Subcellular Location: Nucleus. Tissue Specificity: Expressed in fetal brain. Similarity: Contains 1 HMG box DNA-binding domain. Database links: Entrez Gene: 23152 Human SwissProt: Q96RK0 Human Unigene: 388236 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
