| 產(chǎn)品編號(hào) |
bsk12027 |
| 英文名稱 |
Mouse IL-25/IL-17E ELISA Kit
|
| 中文名稱 |
小鼠白細(xì)胞介素25/17E酶聯(lián)免疫試劑盒 |
| 別 名 |
IL25; IL17E; IL-25; interleukin 25 |
| 克 隆 號(hào) |
|
| 種 屬 |
Mouse |
| 線性范圍 |
31.25-2000 pg/mL |
| 應(yīng)用范圍 |
S/P/CC |
| 檢測(cè)限 |
16 pg/mL |
| 適用樣品基質(zhì) |
cell culture supernates, serum, and plasma. |
| 保存條件 |
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.). |
| 注意事項(xiàng) |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
IL-25 (also known as IL-17E) is a member of the IL-17 family of proinflammatory cytokines, which includes IL-17A, IL-17B, IL-17C, IL-17F and IL-17A/F. IL-17E is found at low levels in various peripheral tissues. It is a proinflammatory cytokine that promotes airway eosinophilia in mice. IL-17E plays a role in Th2 type inflammatory diseases, such as asthma and atopic dermatitis. IL-25 induces elevatedgene expression of IL-4, IL-5 and IL-13 in multiple tissues and results in T helper 2 (TH2)-type immune responses (increased serumIgE levels) and pathologic changes in the lungsand digestive tract with eosinophilic infiltrates, increased mucusproduction, epithelial cell hyperplasia and overall amplified allergicinflammation. IL-25 shares the receptor IL-17RB with IL-17B, although it binds with much higher affinity than IL-17B.
|
|
|
