| 產(chǎn)品編號(hào) | bs-21810R |
| 英文名稱 | FoxP1 Rabbit pAb |
| 中文名稱 | 叉頭蛋白P1抗體 |
| 別 名 | FLJ23741; Fork head related protein like B; Forkhead box P1; Forkhead box protein P1; 12CC4; foxp1; FOXP1_MOUSE; FOX P1; FOXP 1; Glutamine rich factor 1; hFKH1B; HSPC215; MGC12942; MGC88572; MGC99551; QRF 1; QRF1. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 79 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FoxP1 : 521-620/705 |
| 亞 型 | IgG |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Function: Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development. Subunit: Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Subcellular Location: Nucleus. Tissue Specificity: Highest expression in the lung, brain, and spleen. Lower expression in heart, skeletal muscle, kidney, small intestine (isoform 3 not present) and liver. Similarity: Contains 1 C2H2-type zinc finger. Contains 1 fork-head DNA-binding domain. SWISS: Q9H334 Gene ID: 27086 Database links: Entrez Gene: 27086 Human Entrez Gene: 108655 Mouse Omim: 605515 Human SwissProt: Q9H334 Human SwissProt: P58462 Mouse Unigene: 431498 Human Unigene: 59368 Human Unigene: 234965 Mouse Unigene: 485266 Mouse Unigene: 33321 Rat Hox程序的信息輸出并有調(diào)節(jié)運(yùn)動(dòng)神經(jīng)元功能。FoxP1在Hox敏感型運(yùn)動(dòng)柱中表達(dá)，使FoxP1失活能消除運(yùn)動(dòng)神經(jīng)元Hox網(wǎng)絡(luò)的信息輸出，并將脊髓運(yùn)動(dòng)系統(tǒng)回復(fù)到原始狀。 FoxP1的減少同樣改變運(yùn)動(dòng)神經(jīng)元連結(jié)性模式， 肢體運(yùn)動(dòng)神經(jīng)似乎會(huì)隨機(jī)選擇目標(biāo)肌肉和作用路徑。單個(gè)的FoxP1轉(zhuǎn)錄因子能以Hox輔助因子的形式整合各種神經(jīng)元種類的連結(jié)性。 Hox蛋白：哺乳動(dòng)物的同源盒基因由61個(gè)氨基酸殘基組成的蛋白質(zhì)保守結(jié)構(gòu)域,稱同源異型域。Hox基因在動(dòng)物體的體節(jié)結(jié)構(gòu)分化等空間信息調(diào)控中起著重要作用,按特異的空間模式賦予每一體節(jié)其自身的特點(diǎn)。Hox基因不但影響胚胎發(fā)育，在生殖過(guò)程中也起著重要的調(diào)節(jié)作用. |
| 產(chǎn)品圖片 |
Sample:
Spleen (Mouse) Lysate at 40 ug
Primary: Anti- FoxP1 (bs-21810R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 79 kD
Observed band size: 79 kD
Sample:
Cerebrum (Mouse) Lysate at 40 ug
Primary: Anti- FoxP1 (bs-21810R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 79 kD
Observed band size: 79 kD
|
