| 產(chǎn)品編號(hào) | bsm-62671R |
| 英文名稱 | TRIM24 Recombinant Rabbit mAb |
| 中文名稱 | 轉(zhuǎn)錄中介因子Tif1α重組兔單抗 |
| 別 名 | hTIF1; PTC6; RNF82; TF1A; TIF1; TIF1A; TIF1ALPHA; Trim24. |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,IHC-P=1:100-1:200,IHC-F=1:100-1:200,IF=1:50-1:200,ICC/IF=1:50-1:200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 117 kDa |
| 檢測(cè)分子量 | 130 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human TRIM24: 405-455 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). SWISS: O15164 Gene ID: 8805 與許多核受體和輔活化子相互作用并調(diào)節(jié)靶基因轉(zhuǎn)錄的轉(zhuǎn)錄輔活化子。依賴于組蛋白H3修飾與染色質(zhì)相互作用，對(duì)組蛋白H3具有最高親和力，組蛋白H3在“Lys-4”（H3K4me0）處未修飾并且在“Lys-23”（H3K23ac）處乙酰化。具有E3蛋白泛素連接酶活性，促進(jìn)p53/TP53泛素化和蛋白酶體降解。在細(xì)胞增殖和凋亡的調(diào)節(jié)中發(fā)揮作用，至少部分通過(guò)其對(duì)p53/TP53水平的影響。通過(guò)AR、GCR/NR3C1、甲狀腺激素受體（TR）和ESR1上調(diào)配體依賴性轉(zhuǎn)錄激活。通過(guò)維甲酸（RA）受體調(diào)節(jié)轉(zhuǎn)錄激活，包括RAR |
| 產(chǎn)品圖片 |
Western blot analysis of HeLa cell lysate. Using TRIM24 (bsm-62671R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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