| 產(chǎn)品編號 | bsm-61196R |
| 英文名稱 | Phospho-beta Arrestin 1 (Ser412) Recombinant Rabbit mAb |
| 中文名稱 | 磷酸化β-抑制蛋白1重組兔單抗 |
| 別 名 | ARB1; ARR1; ARRB1; Arrestin 2; Arrestin beta 1. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-1:2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 47 kDa |
| 檢測分子量 | 50 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human beta Arrestin 1 around the phosphorylation site of S412: GTG-pS-PQLN |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. SWISS: P49407 Gene ID: 408 β抑制因子-1是調(diào)節(jié)CD4+T細(xì)胞存活和自身免疫性的關(guān)鍵因子，與促進(jìn)T淋巴細(xì)胞存活和自身免疫發(fā)病相關(guān)。經(jīng)研究發(fā)現(xiàn)β-arrestin不僅僅能阻斷蛋白合成，也能誘導(dǎo)蛋白合成，參與信號傳導(dǎo)。 對Arrestins家族的研究-探究β-arrestin在G蛋白偶聯(lián)受體信號傳導(dǎo)通路中的地位和作用，是當(dāng)今生物學(xué)中信號傳導(dǎo)研究領(lǐng)域的熱門課題. β抑制因子-1又稱“胰島素受體復(fù)合體”，近年來國內(nèi)外科研人員對β-arrestin在II型糖尿病發(fā)生的研究機(jī)制方面有了新的突破，認(rèn)為：β-arre |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with Phospho-beta Arrestin 1 (Ser412) monoclonal antibody, unconjugated (bsm-61196R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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